Senior Scientist - TCR Protein/Vector Engineering for Cell Therapy
Location: Gaithersburg, MD
At AstraZeneca, we put patients first and strive to meet their unmet needs worldwide. Working here means being entrepreneurial, thinking big and working together to make the impossible a reality. If you are swift to action, confident to lead, willing to collaborate, and curious about what science can do, then you're our kind of person.
Do you have expertise in, and passion for, protein and vector engineering for TCR-T therapies? Would you like to apply your expertise to shape the next generation of cell therapies in a company that follows the science and turns ideas into life changing medicines? Then AstraZeneca might be the one for you!
About Our Gaithersburg Oncology Hub
Our Gaithersburg, Maryland facility creates life-changing medicines for people around the world. This campus employs more than 3,500 experts in our field and is only a short drive from Washington, DC. This modern and vibrant scientific campus is the home of R&D and Oncology in the US. Here, we host some of the most pioneering technology and lab spaces, all designed to inspire collaboration and cross-functional science. We are dedicated to creating a culture of inclusion and collaboration.
The Gaithersburg site offers a variety of amenities to help keep our employees happy and healthy. This includes a fitness center, employee healthcare clinic, electric vehicle charging stations, dry cleaning, full-service cafeteria, copy center, game rooms, community garden, and much more. This is where you'll find newly-designed, activity-based work spaces to suit a variety of working styles while growing collaboration between teams.
A major focus of the Oncology Cell Therapy team in the Cell Therapeutics and Viral Technologies group is to bring expert capabilities in protein and vector engineering to bear in the development of cell therapeutics. We work closely and collaboratively with colleagues who specialize in tumor biology and immunology, T cell biology, gene editing and high-throughput screening technologies as well as cell product manufacturing in an exciting and newly formed Oncology Cell Therapy Unit within AstraZeneca. Our culture is highly collaborative, fast-paced and innovative.
In this role, you will be focused on protein and vector engineering aspects of TCR-T therapy including the design and optimization of TCRs and related molecules as well as the viral and non-viral vectors used to deliver these proteins into therapeutic cells. You will work closely with a diverse set of colleagues in the exciting new Oncology Cell Therapy Unit at AstraZeneca to deliver cutting-edge oncology cell therapies.
- Ph.D. in biochemistry, molecular biology, cell biology, immunology or other relevant discipline.
Additional Desirable Skills
- Strong understanding of TCR structural biology and structure/function relationships
- Strong molecular biology skills
- Experience with viral and non-viral gene delivery systems and their optimization
- Proven track record of conceiving research projects and carrying out their execution
- Broader immunology knowledge
- Familiarity with design and optimization of CAR-T therapies
- Computational protein design/modeling
At AstraZeneca, any opportunity can be the start of something big. Delivering life-changing medicines is about being entrepreneurial, finding those moments, and recognizing their potential. Join us on our journey of building a new kind of organization to reset expectations of what a bio-pharmaceutical company can be. This means we're opening new ways to work, ground-breaking innovative methods, and bringing unexpected teams together. Interested? Come and join our journey.So, what's next!Are you already envisioning yourself joining our team? Good, because we can't wait to hear from you!
If you're curious to know more, please contact Bobbi Poole, our Talent Acquisition Partner.Closing Date: August 8, 2022Competitive remuneration and benefits apply
We offer a competitive Total Reward program including a market driven base salary, bonus and long term incentive. We have a generous paid time off program and a comprehensive benefits package.Where can I find out more?Our Social Media, Follow AstraZeneca on LinkedIn
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AstraZeneca embraces diversity and equality of opportunity. We are committed to building an inclusive and diverse team representing all backgrounds, with as wide a range of perspectives as possible, and harnessing industry-leading skills. We believe that the more inclusive we are, the better our work will be. We welcome and consider applications to join our team from all qualified candidates, regardless of their characteristics. We align with all applicable laws and regulations on inclusivity in employment (and recruitment), as well as work authorization and employment eligibility verification requirements.
We will ensure that individuals with disabilities are provided reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment. Please contact us to request accommodation.
As part of the application process for some roles at AstraZeneca, candidates may be asked to complete a series of online games, created by pymetrics, to assess certain candidate qualities to help evaluate potential match for the position. If the pymetrics process applies to this role, you will receive an email invitation with additional information following application. Once completed AZ will automatically receive your results - pymetrics will not be used solely in our decision-making process but will help us gather additional insight.
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