Job Info

<p>The laboratory of Dr. Daniel Hollern at the Salk Institute of Biological Studies Department of Immunobiology and Microbial Pathogenesis in La Jolla, California seeks to recruit a Postdoctoral Fellow to engage in immuno-oncology research.</p><p>The main focus of the lab is to understand the immunological and molecular landscape of tumors with the goal of leveraging the immune component to promote anti-tumor immunity. In more detail, the lab is particularly interested in developing these approaches through the study of tumor infiltrating B cells and T cells. These studies will be pursued in syngeneic, orthotopic and genetically engineered mouse models as well as patient specimens. &nbsp;The lab utilizes a multidisciplinary approach blending biologically appropriate models, molecular biology, and genomic analytical&nbsp;techniques including single cell and spatial transcriptomics and proteomics to interrogate pertinent questions in a number of in vitro and in vivo translational studies of breast cancer.</p><p><strong>Position Highlights: </strong></p><ul><li>Be involved in exciting projects to understand B cell and T cell immunobiology in solid cancers and studies exploring novel immunotherapeutic strategies.</li><li>Conduct independent and collaborative studies in an Immunology lab focusing on clinically-relevant translational studies.</li><li>Opportunity to learn techniques in single-cell and spatial computational genomics and immuno-oncology by projects investigating beneficial patient outcomes and anti-tumor immunity.</li><li>Opportunity to develop new models for immune-oncology research.</li><li>Participation at scientific meetings, membership in relevant scientific organizations, and applying for training grants will be encouraged and supported.</li></ul><p><strong>Ideal Candidate:</strong></p><ul><li>Experience with analysis of genomic datasets such as RNA-seq, spatial datasets and single cell sequencing.</li><li>Experience working with lab animals and expertise in the following cellular biology techniques:</li><ul><li>Murine syngeneic and genetically engineered models of cancers as well as allografts/xenografts</li><li>Multi-parameter flow cytometry</li><li>Cell culture</li><li>Elispot or Luminex-based assays for cytokine/chemokine assessments.</li><li>Immunofluorescent staining, imaging and fluorescent microscopy.</li></ul><li>Experience with standard molecular biology assays and genome editing (Crispr).</li></ul><p><strong>Responsibilities:</strong></p><ul><li>Perform investigational studies to understand the tumor microenvironment.</li><li>Execute experiments independently and contribute to collaborative projects.</li><li>Write grants.</li><li>Write manuscripts for publishing.</li><li>Train and supervise junior staff and participate in overall lab management.</li><li>Analyze and present data at local and national meetings.</li></ul><p><strong>Credentials and Qualifications: </strong></p><p>Ph.D. and/or M.D. in Immunology, Cellular/Molecular Biology, or related fields with proven track record of productivity in form of publication in reputable journals. Hands-on-experience in laboratory research and good computer skills are required.</p>